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Symbol
Name
ID

Lep
leptin
MGI:104663

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Decreased T cell activation	Decreased proportion of CD4-positive helper T cells	Recurrent upper respiratory tract infections	Subacute progressive viral hepatitis	Recurrent pneumonia	Recurrent ear infections
Disease(s) Associated with LEP	Decreased T cell activation	Decreased proportion of CD4-positive helper T cells	Recurrent upper respiratory tract infections	Subacute progressive viral hepatitis	Recurrent pneumonia	Recurrent ear infections
congenital leptin deficiency
hepatocellular carcinoma

Mouse Phenotypes

abnormal osteoclast differentiation

decreased T cell proliferation

decreased NK cell number

decreased CD4-positive, alpha-beta T cell number

increased macrophage cell number

decreased spleen weight

decreased splenocyte number

abnormal microglial cell physiology

decreased circulating tumor necrosis factor level

abnormal chemokine secretion

increased interleukin-6 secretion

abnormal acute inflammation

increased susceptibility to endotoxin shock

liver inflammation

lung inflammation

Availability

Mouse Genotype

Lep^m1Yst/Lep^m1Yst

Lep^ob/Lep^ob

Lep^{tm1b(EUCOMM)Hmgu}/Lep^{tm1b(EUCOMM)Hmgu}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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